Two studies published in Journal of Ocular Pharmacol Ther in 2010 & 11 shows that cyclosporine ophthalmic emulsion is more effective than artificial tears in the management of dry eyes.
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Study:
58 dry eye patients were recruited for this study. In the first year of study 36 patients received cyclosporine (Cs) whereas 22 patients received Artificial Tears (AT).
In the second year of study 22 out of 36 patients from previously treated Cyclosporine were continued with the same treatment and 8 we switched to Artificial Tears. On the other hand, 20 patients who received Artificial Tears in the first year of study were switched to cyclosporine.
Results:
1. At the end of 1 year Patients treated with Cyclosporine 0.05% showed significant improvement in Schirmer score, TFBUT and OSDI than Artificial Tears.
Patients treated with Cyclosporine 0.05%in 2nd year showed significant improvement in Schirmer score, TFBUT and OSDI
2. Patients switched to AT from Cyclosporine 0.05% worsened their dry eye
3. Consistent significant improvement in goblet cell density in the patients treated with Cyclosporine 0.05%
"Cyclosporine ophthalmic emulsion 0.05% offers better relief in Dry Eye signs and symptoms when compared with Artificial Tears with significan improvement in goblet cell density."
58 dry eye patients were recruited for this study. In the first year of study 36 patients received cyclosporine (Cs) whereas 22 patients received Artificial Tears (AT).
In the second year of study 22 out of 36 patients from previously treated Cyclosporine were continued with the same treatment and 8 we switched to Artificial Tears. On the other hand, 20 patients who received Artificial Tears in the first year of study were switched to cyclosporine.
Results:
1. At the end of 1 year Patients treated with Cyclosporine 0.05% showed significant improvement in Schirmer score, TFBUT and OSDI than Artificial Tears.
Patients treated with Cyclosporine 0.05%in 2nd year showed significant improvement in Schirmer score, TFBUT and OSDI
2. Patients switched to AT from Cyclosporine 0.05% worsened their dry eye
3. Consistent significant improvement in goblet cell density in the patients treated with Cyclosporine 0.05%
"Cyclosporine ophthalmic emulsion 0.05% offers better relief in Dry Eye signs and symptoms when compared with Artificial Tears with significan improvement in goblet cell density."