A. Cyclodrop in Post Lasik Dry Eyes:
Cyclosporine helps in post lasik dry eyes by-
- Preventing MMP (Matrix Metalloproteinase) mediated breakdown of corneal barrier integrity
- Improves corneal nerve sensitivity and promotes corneal nerve regeneration.
- Faster improvement in Visual Acuity
- Decreases corneal haze
- In comparison with preservative free artificial tears better response is observed with the use of cyclosporine in post lasik patients.
B. Cyclodrop in Vernal keratoconjunctivitis (VKC) and Atopic keratoconjunctivitis (AKC):
Cyclosporine helps in patients of VKC by-
- Inhibition of fibrosis and inflammatory cell infiltration by the suppression of cytokine production from T cells in repeatedly antigen-challenged conjunctiva.
Cyclosporine helps in patients of AKC by-
- Significant reduction in symptoms (Itching, tearing, discomfort, mucous discharge, and photophobia) and signs (bulbar conjunctival hyperemia, upper tarsal conjunctival papillae, punctate keratitis, corneal neovascularization, cicatrizing conjunctivitis, and blepharitis) of AKC by inhibiting T cell activation when used in steroid resistant cases.
C. Cyclodrop in keratoconus patients:
Cyclosporine helps in keratoconus patients by-
- Decreasing MMP and interleukins levels in the eyes of keratoconus patients.
D. Cyclodrop in patients of Meibomian Gland Disease (MGD):
Cyclosporine helps in MGD patients by-
- By inhibiting T cell activation,cyclosporine decreases the inflammation of the meibomian gland.
- Cyclosporine has been shown to ameliorate the ocular symptoms and signs of dry eyes by modulating the immune cell populations of both the conjunctiva and the lacrimal gland.
E. Cyclodrop helps in patients with glaucoma after long term usage of topical anti-glaucoma drugs:
Chronic administration of glaucoma medications causes a decrease in the number and density of corneal sub basal nerve fiber layer.
Cyclosporine helps in these patients who are on ocular hypotensive drugs by-
- Improving corneal sensitivity
- Increasing corneal sub basal nerve fiber density SBNFL
F. Cyclodrop after pterygium surgery:
Cyclosporine helps in patients after pterygium surgery by-
- Preventing the conjunctival autograft rejection
- Preventing recurrence of pterygium:
G. Cyclodrop in the management of recurrent Anterior Uveitis
Cyclosporine helps in patients with recurrent anterior uveitis by-
- Reducing frequency and severity of recurrences in patients with recurrent anterior uveitis
H. Cyclodrop in the management of recovery of corneal sensation following Cataract Surgery
Cyclosporine helps in post cataract surgery by-
- Cyclosporine is effective and safe in the management of ocular surface problems after cataract surgery and allows faster recovery of corneal sensation when compared with CMC.